Job Title: Research Fellow
Working Title: Research Fellow
Job Family: Research
FLSA: Exempt

Department: Oncology (Cancer Epigenetics and Therapeutic Resistance)

Reports to: Principal Investigators: Drs. Eneda Toska and Elana Fertig

The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University is recruiting an individual to lead analyses on epigenomics analyses such as (ChIP-seq, ATAC-seq and RNA-seq) and single cell analyses in cancer models. This person will be active in the data pre-processing stages as well as analysis and interpretation of results.

The Toska lab integrates biochemistry, cell signaling, genomics and epigenomics at bulk and single cell level to study the fundamental processes by which epigenetic regulators regulate transcription, have the ability to drive tumorigenesis and dictate therapeutic response in breast cancer. The Fertig lab develops time course models of therapeutic resistance and performs single cell technology development. Her computational methods are used to determine the molecular mechanisms of therapeutic resistance from multi-platform genomics and epigenomics data. The successful candidate will become a fundamental component of this multidisciplinary team with mentorship in both computational and biological processes affecting therapeutic response in cancer.

Eligible candidate will be involved in designing and developing analysis plans to address biological hypotheses in our ChIP-seq/ATAC-seq/RNA-seq and RNA-seq and ATAC-seq at the single level acquired from breast cancer models such as cell lines, organoids, and patients treated with targeted therapies. The candidate will interact daily with other data analysts within the Institute, as well as Genomics experts, and clinicians. This position requires collaboration with clinical and scientific investigators in research/study design, data analysis plans, algorithm development, grant applications, and preparation of presentations and publications. The candidate should work independently and in collaboration with faculty to solve problems posed by the clinical and laboratory investigators along the study design, data generation, collection and management process; interaction with bioinformatic experts, biostatistician program developers, computational scientists, health informatic experts as well as postdoc fellows from the Sidney Kimmel Comprehensive Cancer Center and the Bloomberg School of Public Health on our epigenomic data mining initiatives with the goal of translating these findings into therapeutic modalities for cancer patients. The applicant may share efforts between 1-3 labs.

DUTIES AND RESPONSIBILITIES

• Plan data management including determining type, format of data and types of documentation, considering privacy, confidentiality and other ethical issues
• Facilitate acquisition of single cell sequencing data from core facilities
• Clean data by coding missing data, fixing or deleting miscoded data, transforming variables into more useful formats, and annotating the data in proper way, use descriptive statistics to help characterize and summarize the data
• Collaborate with clinical and scientific investigators in the breast cancer and biostat teams to propose ideas for new projects, design research, develop data plan, and prepare analyses with general direction from investigators
• Apply different technical approaches to visualize the data and prepare publication-quality tables and graphs based on valid analysis
• Lead or participate actively in the team responsible for designing and validating analysis data sets, programs, and statistical output products
• Identify potential data problems from analytic queries and bring them to the attention of the team.
• Demonstrate understanding of high dimensional data collection processes and data sets and share knowledge with collaborators.
• Collaborate closely with investigators, and other team leadership to ensure that research study or project results and conclusions are presented accurately and without bias.
• Demonstrate progress in ability to multi-task and manage time spent working with individual faculty members and on specific projects.
• Participates in regularly schedule meetings with study investigators and team. Prepares progress reports as needed. Maintain appropriate systems for data organization.
• Assure data quality for documentation and dissemination of data. Conduct and track specific activities to accomplish project goals, including evaluating and reporting data and documenting analytic procedures.
• Able to work collaboratively in a team environment with a high degree of initiative and self-motivation.

Supervision of Others:

NA

Equipment, Machine, or Tool Requirements:

• Experience with computers and servers and knowledge of Linux/UNIX as well as other common operating systems such as Mac OS and Windows is necessary.
• Experience with server configuration and troubleshooting preferred.
• Ability to use the internet and web-based scholarly search engines.

REQUIREMENTS

Minimum Qualifications:

Education:

Required: Bachelor’s Degree in Statistics, Computer Science Bioinformatics and PhD in Statistics, Computer Science Bioinformatics or related field

Experience:

• Minimum of 3-4 years related experience in analyzing genomic data
• Experience with code development, optimization, and testing

Licensure, Certification, Registration:

NA

Special Knowledge, Skills, or Abilities / Competencies:

• Proficiency with bioinformatics concepts, methods, and tools, with experience working in languages such as R or Python, leveraging Bioconductor and bioconda.
• Coursework or work experience covering topics in statistics, molecular biology, genetics, and script-level programming.
• Proficiency with genomic data, tools, and databases.
• Familiarity with common computational biology tools.
• Experience with experimental design principles, reproducible research principles,
• and data storage, security, and safety.
• Excellent interpersonal skills in consulting with researchers and understanding
• their problems.
• Excellent writing and verbal skills in the preparation and presentation of reports.
• Excellent organizational skills and attention to details are required.
• Must be detail-oriented, focused, creative, and independent
• Proficiency in both written and spoken English with excellent communication

Skills

• Familiarity with common computational biology tools and software packages, such as Bioconductor
• Familiarity with cancer epigenetics is preferred

Contact Information:
Dr. Eneda Toska

etoska1@jhmi.edu

 

The Department of Anesthesiology and Critical Care Medicine (ACCM) and the Armstrong Institute Center for Health Care Human Factors (www.hopkinsmedicine.org/armstrong/humanfactors) at the Johns Hopkins University School of Medicine is recruiting a postdoc research fellow and/or a research coordinator.

The ideal applicant will have experience in human factors engineering, cognitive systems engineering, human computer interaction, human factors psychology, or a related field. Experience in health care related work is highly desired, though not required. Experience or interest in both qualitative and quantitative analysis methods is also desired.

The fellow will primarily be working with James H Abernathy, III, MD, MPH along with Ayse Gurses, PhD and other research team members on one or more funded research projects in the areas of human factors in patient safety and/ or health informatics. The individual will also have the opportunity to collaborate with other interdisciplinary research members of ACCM and the Armstrong Institute for Patient Safety and Quality.

Primary Responsibilities:

• Work collaboratively with study team on federally funded patient safety and human factors engineering-based research projects
• Manage and perform data collection activities
• Assist in the analysis and management of data (both qualitative and quantitative data analysis)
• Assist in the preparation of study protocols and materials (e.g., IRB) and other essential functions
• Conduct literature reviews and summarize findings
• Author/co-author research manuscripts
• Help with writing grant proposals, lead writing career grants (if interested and applicable)
   

Education:

• PhD or Master’s level degree or equivalent is required. Individuals with clinical backgrounds with interest in research will also be considered.
   

Experience & Required Skills:

• An individual with formal training and experience in human factors, cognitive systems engineering, human computer interaction, macroergonomics, sociotechnical systems design, or a related field.
• An in-depth understanding of human cognition and usability design principles as they pertain to the design of technology to support and facilitate work (individual work and teamwork)
• Knowledge of sociotechnical system approaches to research and design; an understanding of work system redesign to improve processes and outcomes.
• Good understanding of related research processes and methodologies including qualitative and quantitative research methods.
• Experience with knowledge elicitation methods (e.g., interviews, focus groups, and contextual inquiry), data driven design, iterative design processes, user-centered design, prototyping, and usability evaluations
• Strong interest in conducting field research in health care environments
• Ability to work independently as well as collaboratively as part of a research team
• Ability to balance and prioritize tasks, and delivers timely outcomes
• Excellent problem solving, organizational, writing and communication skills
   

Nice to Have:

• Knowledge/experience in ecological interface design and related design philosophies
• Experience with prototyping methods and prototyping software (Adobe Creative Suite, PowerPoint, Balsamiq etc.)
• Knowledge/experience with software/coding languages appropriate for the development of interfaces/ health IT
• Experience with conducting usability evaluations (formative and summative)
• Experience in research processes and qualitative methodologies for data collection & analysis, with corresponding software experience (e.g. semi-structured interviews, and thematic analysis with NVivo)
• Familiarity with quantitative analysis methods and corresponding software experience (e.g., statistical analysis with SPSS)
• Familiarity with the healthcare domain and experience conducting research in healthcare.
• Experience in IRB protocol preparation
   

Application deadline:

• No specific deadline. However, applicants are encouraged to apply for the position as soon as possible. This position has an immediate starting date.
• Apply now by sending applications to Carol Stokeling at cstokel1@jhmi.edu
• Please provide a cover letter, CV, names and contact information of three references, and a personal statement (600 words max).

The Trapecar Lab at the Johns Hopkins All Children’s Hospital and Institute for Fundamental Biomedical Research in St. Petersburg, Florida, is looking to hire two postdoctoral scientists.

The focus of the group is the exploration of fundamental origins of immunometabolic diseases, such as IBD, metabolic syndrome and neurodegenerative disorders, by using exciting, multiorgan human-on-a-chip technologies and systems biology. To get a sense of the approach please consult www.trapecarlab.org and see two recent papers: Trapecar et al., Cell Systems 2020 and Trapecar et al., Science Advances, 2021.

An ideal candidate will have strong conceptual and practical experience in two or more of the following areas: immunology, stem cell biology, molecular biology and tissue engineering. Types of tissues and organs that the lab is particularly interested in are mucosal tissue like intestine and lungs, liver, neuronal and adipose tissue as well as a wide range of circulating and tissue-resident immune cells. Common techniques used in the lab are cell culturing (primary cells, organoids, iPS cells), flow cytometry and cell sorting, generation and analysis of transcriptomic as well as metabolomic data (Chipseq, scRNAseq…), confocal microscopy, multiplexed cytokine/chemokine analysis (ELISAs, Luminex) and use of bioengineered tools like human-on-a-chip platforms to study human multiorgan interactions.

Successful candidates must be capable to work in highly multidisciplinary research teams and have a demonstrated track record of success in independent scientific research. Strong applicants will exhibit significant basic science understanding, scientific rigor, motivation, and an ability to originate, carry out, and publish significant original research in collaboration with their JHU mentors. Strong written and verbal English language skills are required.

The rapidly growing new Institute for Fundamental Biomedical Research is part of the Johns Hopkins All Children’s Hospital in St. Petersburg, Florida, and the Johns Hopkins University (JHU) School of Medicine ecosystem. It represents a superbly equipped research environment that aims to connect basic and clinical researchers to solve some of the biggest medical challenges. Trainees and postdoctoral scientists have also full access to resources available at the main JHU Baltimore campus and are strongly encouraged to participate in JHU-wide activities and collaborations. The lab and institute are fully committed to the candidate’s career development and path to independence.

St. Petersburg offers a great quality of life in terms of affordability, pristine nature, close proximity to Tampa bay’s international airport, and vibrant cultural life.

If interested in the position, please submit a CV and brief description of scientific interests to mtrapec1@jhmi.edu.

Job Description:
The Johns Hopkins University Department of Dermatology Cutaneous Oncology Fellowship Program offers a unique clinical and research experience across the disciplines of cutaneous oncology including cutaneous lymphoma, melanoma, skin cancer in high risk/ immunocompromised (solid organ transplant patients) and supportive oncodermatology. Fellows will work with our expert clinicians and physician scientists, to gain skills in clinical and translational research. The clinical fellows are expected to productively participate in the clinical and translational research activities of the Department of Dermatology, publish scholarly clinical research articles during their fellowship and make at least one scientific presentation. Fellows will assist in developing protocols for clinical research studies, work with the Institutional Review Board (IRB), recruit study patients, conduct study visits, and learn/ improve data management skills. Fellows will also interact with pathology, oncology and transplant teams in multidisciplinary patient care. They will work with basic scientists on translational research projects. Fellows will have the opportunity for organizational leadership role in organizing local cutaneous oncology meetings.

Requirements
Position open to:

3rd to 5th year medical student or

MD or MD/PhD degree and completion of at least 1 year PGY1 residency (by June 30) or

Fellows may also have already completed dermatology residency

Updated CV and 3 references
All available USMLE transcripts (e.g., Steps 1, 2 CK, 2 CS and 3)
Maryland State Medical License; at the time of the beginning of the fellowship (July 1), if applicable
Preference will be given to those who have completed a residency in internal medicine or dermatology and have an interest in an academic career.
Interested applicants should send a brief statement of their interests and career goals with the aforementioned items

Dates
This is a one to two-year fellowship upon mutual agreement. Each appointed term runs from July 1st through June 30th, or upon agreement.

Contact:
Courtney C. Elcock
Sr. Administrative and Development Coordinator
(410)955-8662
(410)955-8645(fax)
celcock1@jhmi.edu

Primary Faculty: Darrell J. Gaskin, Ph.D.

This announcement is for a postdoctoral fellowship in the Training in Orthopedic Team Science (TOTS) program at the Bloomberg School of Public Health at Johns Hopkins University. The postdoctoral fellow will work with a multidisciplinary team from the Bloomberg School of Public Health and the Department of Orthopedic Surgery in the School of Medicine. This multidisciplinary team will investigate the economic implications of issues of diversity within the field of orthopedics for patients and providers. This team will consist of the postdoctoral fellow, an orthopedic surgery resident physician trainee, a clinical mentor and research mentor.

This position is funded by a T32 grant from the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) of the National Institutes of Health. This postdoctoral position has a two-year training period. The postdoctoral fellow will work in partnership with an orthopedic surgery resident physician trainee to apply experimental research methods in economics to musculoskeletal healthcare disparities. One of the goals of this program is for the resident and the postdoctoral fellow to develop complementary projects on disparities in musculoskeletal healthcare.

The postdoctoral fellow will be mentored by Darrell J. Gaskin, PhD, Director of the Johns Hopkins Center for Health Disparities Solutions and the William C. and Nancy F. Richardson Professor in Health Policy. The TOTS team will include an orthopedic surgery resident physician trainee and their clinical mentor from the Department of Orthopedic Surgery. This is an in-person position; however, while COVID pandemic protocols are in place, the postdoctoral fellow will be expected to work from home.

Only U.S. citizens, non-citizen nationals, or those lawfully admitted for permanent residence are eligible for this position.
Qualified applicants for the postdoctoral fellowship should have the following:

1) A Ph.D. in Economics, Health Economics, Epidemiology, or related field. (It is possible to apply for the position if one expects to achieve a doctoral degree by June 30, 2021).
2) Ability to conduct independent economic research, apply experimental methods to healthcare economics, and assume responsibility for the development and completion of research papers.
3) Demonstrated ability to work as part of a research team on collaborative projects with successful completion of project aims and deadlines.

Applications will be considered on a rolling basis until the position is filled. Please submit applications via email to Dr. Darrell J. Gaskin at HCHDS@jhu.edu.

Completed applications should include:
1) A 2-page research statement describing one’s research interests and how they relate to disparities in musculoskeletal healthcare.
2) A current CV.
3) A job market paper.
4) A letter of support from one’s dissertation advisor or a member of their dissertation committee.
5) Two letters of recommendation.

General Description
We are seeking recent Ph.D. graduates to join a postdoctoral fellowship program developing approaches to clinically relevant molecular characterization of patient-derived three dimensional models of pancreatic cancer. The fellowship program is jointly advised by faculty from the Department of Surgery and Oncology as part of the Pancreatic Cancer Multidisciplinary Laboratory and the Pancreatic Cancer Precision Medicine Center of Excellence at Johns Hopkins Hospital and Johns Hopkins Medical Institutions. This unique opportunity will allow postdoctoral fellows to gain academic research experience with direct translational relevance and implementation of patient-centered clinical research projects. Successful candidates will have an interest in improving techniques in rapid tumor modeling and clinically-relevant characterization from patient-derived tissues.

Our laboratory leverages high patient case volumes and an extensive clinical trials network to establish and maintain a large living biobank of patient-derived organoid cultures. These models are used to understand the key drivers that govern system behavior and to explore potential therapeutic approaches. We are currently using high-throughput technologies to characterize clinically-actionable genotype and pharmacotype in efforts to guide precision medicine initiatives. Additional opportunities for academic scholarship include techniques to study molecular biology of epithelial-cancer associated fibroblast interactions, microRNA gene regulation, and immunotherapeutic applications in pancreatic cancer. The laboratory maintains active collaborations with both intramural and extramural researchers as the lead site in translational research stemming from SU2C/Lustgarten foundation funded clinical trial NCT#03563248.

The fellowship provides an annual salary commiserate with NIH guidelines for PGY level with full healthcare benefits. Postdoctoral scientists will be employees of Johns Hopkins University. Applicants are not required to be United States citizens

How to apply:

• Cover letter including a) description of suitability of this position and b) career goals including and following the postdoctoral position.
• CV including publications, presentations, and other relevant experience.
• List of referees, with contact info and description of their relationship to the applicant.

Email application materials to Dr. Richard Burkhart (rburkha6@jhmi.edu)

A postdoctoral position is available for a highly motivated individual to join the Alaish laboratory in the Division of Pediatric Surgery at the Johns Hopkins School of Medicine.

The Alaish laboratory focuses on the molecular mechanisms underlying short bowel syndrome. The complications of short bowel syndrome including Intestinal barrier loss, cholestasis and intestinal dysbiosis are investigated with the goal to design novel therapies directed at specific sites in the molecular pathways. A major component of this translational research is the use of genetically engineered mice as a model for short bowel syndrome.

Requirements:

Candidates should hold a doctorate degree with a background in molecular biology, cell biology, genetics, biochemistry or a related field.

Candidates with experience in performing surgery on mice are preferred.

Candidates with a record of research excellence demonstrated by publication will be favored.

Applicants who are motivated to develop careers as independent investigators are especially encouraged to apply.

Proficiency in creating tables and figures appropriate for journal publication is required.

Proficiency in verbal and written English is required.

Interested candidates should send their CV, a brief letter outlining their future research goals, and names and contact information for at least two references to:

Samuel M. Alaish, M.D.
Associate Professor of Surgery
Surgical Director, THRIVE Pediatric Intestinal Rehabilitation Program
Division of Pediatric Surgery
Johns Hopkins School of Medicine
salaish1@jhmi.edu

The Department of Surgery at the Johns Hopkins University School of Medicine is seeking a highly motivated postdoctoral research fellow to join our NIH-funded research group directed by Dr. Hongpeng Jia.

The research projects of the lab utilize cutting-edge interdisciplinary research approaches and aim to understand how the host response to viral and bacterial lung infection. In particular, The Jia lab will dissect the critical role of, and therapeutic potential for Angiotensin Converting Enzyme 2 (ACE2) in COVID-19 and Influenza viral infection and associated secondary bacterial/viral superinfection. Multiple novel inducible transgenic and gene targeting murine models, genome sequencing analysis, CRISPR gene editing, 3D lung organoid models, and single-cell RNA-seq techniques will be involved in the ongoing research projects

Candidates should have a PhD and/or MD or equivalent degree, with a strong background in Virology, Immunology, especially Innate immunity and is eligible of working in the united states. The candidates must be enthusiastic toward research projects, and have excellent critical thinking skills, a track-record of productivity as demonstrated by first-author peer-reviewed publications, an ability to work well both independently and as part of a team, and proficiency in written and oral English communication.

A successful candidate will have the opportunity to lead independent and cutting-edge research projects with a world-class research facility. We will also provide a customizable curriculum, individual career development/support, and Interdisciplinary and collaborative research community.

Salary will be commensurate with research experience.

To apply, please send 1) a cover letter with a brief statement of research experience and future proposed interests, 2) contact information of at least 3 references (at least one from former direct mentor) , and 3) a detailed curriculum vitae to: Dr. Hongpeng Jia by email: hjia4@jhmi.edu

Hongpeng Jia
Assistant Professor
Division of Pediatric Surgery
Department of Surgery
Johns Hopkins University School of Medicine
Office: 735A Ross Building
Tel: 410-955-3429
Lab: 733 Ross Building
Tel: 410-614-0568
1721 E Madison Street
Baltimore, MD 21205
Email: hjia4@jhmi.edu

PI: Ronadip Banerjee, MD, PhD 

 Job Description:
The Banerjee Lab in the Division of Endocrinology, Diabetes & Metabolism, at the Johns Hopkins School of Medicine is seeking to hire a postdoctoral fellow to lead and develop new research project(s).

The focus of the lab is pancreatic islet biology and elucidating novel molecular mechanisms underlying diabetes. We are currently focused on understanding how islets within pregnant mothers adapt to the changing metabolic requirements during pregnancy and the postpartum.  We hope to identify how dysregulation of these processes leads to gestational diabetes, and the future risk of type 2 diabetes in mothers postpartum. To address these questions, we use a variety of techniques in molecular biology, cell biology, and genetics, including single-cell RNA sequencing, mouse genetic models, in vivo metabolism studies, immunohistochemistry, etc. The lab also has expertise and tools to study prolactin receptor (PRLR) biology and is examining its role both in islets and other tissues. Additional information can be found at the lab website:  https://www.rrbanerjeelab.org/

The lab recently relocated to the Johns Hopkins School of Medicine and is supported by both NIH (R01) and startup funds, permitting highly motivated candidates the resources and freedom to pursue any of several projects. 

Requirements:
An MD and/or PhD in a science-related field, excellent written and verbal communication skills, strong work ethic and the ability to work interactively are required.?Willingness to work with animal models and human islets is required; prior experience with mouse models is highly desirable. Experience in islet biology or diabetes is desirable but not essential. Postdocs who are strong candidates for postdoctoral fellowships are strongly preferred.? 

How to apply:
We are?actively searching for a postdoctoral fellow to begin as soon as possible in Fall 2021. To apply, please send a CV, cover letter, and contact information for at least 3 references to Dr. Banerjee at rrbanerjee@jhmi.edu. The positions will remain open until filled. Salary and fringe benefits will be compliant with guidelines established by the Johns Hopkins University School of Medicine.

• A NIH/DOD funded postdoctoral research position with benefits
• Salary following NIH NRSA scale

Postdoctoral positions are available immediately for highly motivated scientists to investigate multiple innovative aspects of breast cancer including the role of microbiome in breast cancer growth, metastatic progression and response to therapy. Project also involves investigations related to development of drug resistance, role of obesity/adipocytokines, tumor microenvironment and racial disparity in breast carcinogenesis.

Candidates must hold a doctoral-level degree with solid background in cancer biology, molecular and cellular biology. Experience in techniques related to signal transduction, gene expression, tumor biology, and animal models is required. Experience in immunology, metabolic pathways and microbiome is desirable.

Interested applicants should send the following materials in an application packet, preferably as a single PDF file, by email to Dr. Dipali Sharma (dsharma7@jhmi.edu)

1. Cover letter indicating current and future research interests,
2. Expected starting date
3. Curriculum vitae
4. Brief summary of previous research experience (2-3 pages)
5. Names and contact information for 3 references

Primary faculty: Dr. Sheree Schwartz

Description of position:
The Johns Hopkins University Center for AIDS Research Implementation Science Core is looking for a highly motivated Postdoctoral Research Fellow to support in the enhancement the short- and long-term scientific rigor and relevance of IS studies and to increase collaboration to promote generalizable knowledge to end the HIV epidemic in the US. The position involves leading and supporting analyses and manuscript development contributing to the advancement of meta-science HIV initiatives and implementation science methodological development applied to the HIV field. Drs. Sheree Schwartz and Stefan Baral will serve as the primary faculty mentors for the post-doctoral Fellow, however the Fellow will have the opportunity to work with a larger bench of HIV and implementation science faculty.

Why you should join our team

1. You would be working with an accomplished and supportive group of investigators eager to see you learn, grow, and succeed.
2. We have an incredibly vast database of HIV related implementation science literature available for analysis, with many opportunities to explore your own interests, lead first-author publications and conference presentations, and generate preliminary data for future studies
    

The fellow’s responsibilities will include:

1. Leading and conducting meta-research using large datasets of implementation science literature addressing HIV and other infectious diseases.
2. Disseminate findings in the form of first author publications and abstract presentations.
3. Collaborate with a highly productive team of investigators from the Mid-Atlantic Center for AIDS Research Consortium Implementation Science Technical Assistance Hub at Johns Hopkins University, the Dissemination and Implementation Center at Washington University in St. Louis, and Emory University.
    

Qualifications:

1. Strong interest in and demonstrated experience and knowledge of implementation research.
2. Experience in systematic reviews, meta-analyses, and/or meta-research preferred.
3. Technical expertise and/or knowledge of HIV preferred.
4. Graduates from PhD programs in public health or related fields; preference will be given to candidates with PhDs in implementation science or completion of related certificates and/or coursework.
    

Notable publications include:
Schwartz SR, Smith JD, Hoffmann C, Hansoti B, Mishra S, Means AR, Go V, Sherr K, Nash D, Sullivan P, Baral S. Implementing Implementation Research: Teaching Implementation Research to HIV Researchers. Curr HIV/AIDS Rep. 2021 Jun;18(3):186-197. doi: 10.1007/s11904-021-00551-4. Epub 2021 Mar 11. PMID: 33709323.

Eshun-Wilson I, Jamil MS, T Charles W, Glidden DV, Cheryl J, Noelle T, Ford N, McGee K, Chris K, Stefan B, Schwartz S, Elvin GH. A systematic review and network meta-analyses to assess the effectiveness of HIV self-testing distribution strategies. Clin Infect Dis. 2021 Jan 20:ciab029. doi: 10.1093/cid/ciab029. Epub ahead of print. PMID: 33471087.

Eshun-Wilson I, Awotiwon AA, Germann A, Amankwaa SA, Ford N, Schwartz S, Baral S, Geng EH. Effects of community-based antiretroviral therapy initiation models on HIV treatment outcomes: A systematic review and meta-analysis. PLoS Med. 2021 May 28;18(5):e1003646. doi: 10.1371/journal.pmed.1003646. PMID: 34048443; PMCID: PMC8213195.

Schwartz SR, Rao A, Rucinski K, Lyons C, Viswasam N, Comins CA, Olawore O, Baral S. HIV-Related Implementation Research for Key Populations: Designing for Individuals, Evaluating Across Populations, and Integrating Context. J Acquir Immune Defic Syndr. 2019 Dec;82 Suppl 3(Suppl 3):S206-S216. doi: 10.1097/QAI.0000000000002191.

Baral S, Rao A, Sullivan P, Phaswana-Mafua N, Diouf D, Millet G, Musyoki H, Geng E, Mishra S. The disconnect between individual-level and population-level HIV prevention benefits of antiretroviral treatment. Lancet HIV. 2019 Sep;6(9):e632-e638. doi: 10.1016/S2352-3018(19)30226-7. Epub 2019 Jul 19. DOI: 10.1016/S2352-3018(19)30226-7.

Any questions should be directed to Research Program Coordinator, Anna-Sophia Katomski, akatoms1@jhmi.edu.

Instructions for applying:
Interested applicants should submit the following documents to akatoms1@jhmi.edu;

1. Cover letter indicating research interests and relevant qualifications.
2. Curriculum Vitae (CV)
3. 2 letters of recommendation

Applications will be considered on a rolling basis until the position is filled. Preference given to an early start date.

Primary faculty: Fengyi Wan

Description of position:
Two postdoctoral positions are available in the laboratory of Dr. Fengyi Wan at the Johns Hopkins University Bloomberg School of Public Health (https://publichealth.jhu.edu/faculty/2472/fengyi-wan) to study 1) the molecular and cellular mechanisms in bacterial infection-associated lethal colitis and colon tumorigenesis and 2) the DNA damage-initiated signal transduction in the normal and cancerous colon epithelial cells. Our work utilizes a combination of mouse models, immunology, molecular biology, genetics, and genomics to elucidate crucial host-pathogen-microbiota interactions and signal transduction cascade in the immune responses and DNA damage responses under multiple pathophysiological conditions. A complete listing of PubMed-accessible publications can be found at https://www.ncbi.nlm.nih.gov/sites/myncbi/12o_n2vSCEI5-/bibliography/48138105/public/?sort=date&direction=descending. The successful applicant should have self-motivation and a strong record of independent research. We welcome applications from diverse backgrounds and candidates with expertise in signal transduction, microbiology, immunology, genetics, or cancer biology are strongly encouraged to apply.

Instructions for applying:
Applications should be sent to Dr. Fengyi Wan (fwan1@jhu.edu), with a statement covering the candidate’s motivation and research experience, a CV, and the contract information of two referees. Applications will be considered until the positions are filled. The Johns Hopkins University is an Affirmative Action/Equal Opportunity Employer.

NIH-funded postdoctoral positions are open in the laboratory of Dr. Jeff Mumm at the Johns Hopkins University in Baltimore Maryland, USA. Selected candidates will lead a project to create novel resources for dissecting cell subtype function, and enabling investigations of cellular regeneration in the nervous system.

Ideal candidates will have recently obtained their Ph.D or M.D./Ph.D degrees in the field of Regenerative Biology, Biochemistry, Molecular Biology, Ophthalmology or an equivalent field. In addition, we welcome applications from diverse backgrounds and encourage candidates with expertise in signal transduction, immunology, or genetics to apply. The project will require mastery of state-of-the-art molecular, cellular, and imaging techniques, including CRISPR/Cas-based knock in gene targeting. Candidates should have prior experience with targeted transgenesis. The successful applicant should be self-motivated with a proven record of independent research. Project leaders will be given the opportunity to participate in ongoing related research in the lab and to develop their own independent research program.

Interested individuals should send the following material to Dr. Jeff Mumm: jmumm3@jhmi.edu:

1. Cover letter indicating current and future research interests
2. Expected starting date
3. Curriculum vitae
4. Brief summary of previous research experience (1-2 pages max)
5. Names and contact information for 3 references
    

Applications will be considered until the positions are filled. Johns Hopkins University fosters intellectual interaction, provides state-of-the-art resources, and embraces diversity in our workforce.

The Mesubi lab at The Johns Hopkins School of Medicine, Division of Cardiology is actively seeking to recruit a highly motivated postdoctoral fellow to join our lab. Research in our lab is currently focused on understanding the role of the posttranslational modification – O-GlcNAcylation in atrial fibrillation. Our goal is to understand novel fundamental mechanisms of atrial fibrillation and translate this knowledge into development of new therapies for atrial fibrillation. Research in our lab encompasses O-GlcNAc biology, CaMKII biology, intracellular calcium signaling, mitochondrial energetics, atrial fibrillation, and diabetes.

Postdoctoral research fellows will be part of a rich and collegial scientific research community at Johns Hopkins University with access to state-of-the-art research facilities and numerous opportunities for collaboration across the Hopkins campus. Salary and fringe benefits will be compliant with guidelines established by the Johns Hopkins University School of Medicine.

Requirements

• The postdoctoral fellow will work on basic cellular electrophysiology and mouse electrophysiologic studies.
• Glycobiology, OGlcNAc biochemical assays, cloning, expression and purification of proteins, cell culture, enzyme activity assays.
• Cardiac metabolism and mitochondrial energetics.
• Generation of genetic mouse models, and gene editing (e.g. CRISPR, shRNA).
• Ryanodine receptor type 2 (RyR2) and CaMKII biology, protein immunoprecipitation.
• Application of omics technologies - transcriptomics, proteomics and metabolomics.

Qualifications

• Highly motivated candidates with a PhD or MD, or other equivalent doctoral degree in biomedical sciences or biomedical engineering and experience in basic cellular electrophysiology, biochemistry or molecular biology are encouraged to apply.
• Experience and/or expertise in basic cellular electrophysiology and intracellular calcium dynamics is preferred.
• Skills in biochemistry, mitochondrial biology, mouse work, gene manipulation, immunoprecipitation, cell culturing techniques/protein expression are highly desirable.
• Strong analytical skills.
• Candidate should have excellent writing and communication skills, able to work independently but also effectively with other lab members.

To learn more and apply, please send

• A Cover Letter or short statement of research goals
• Curriculum vitae
• 2 3 letters references to Olurotimi Mesubi, MBBS, MPH @ olurotimi.mesubi@jhmi.edu

A postdoctoral position is available in the Braunstein laboratory in the Division of Hematology at the Johns Hopkins School of Medicine in Baltimore, MD. We are seeking a creative and highly motivated postdoctoral researcher to join our team and lead the efforts to uncover and characterize the genetic mechanisms driving pathogenesis of complement mediated hematologic diseases.  

Prior research in the Braunstein Lab has identified a role for complement in the pathogenesis of multiple disorders including catastrophic antiphospholipid  antibody syndrome (CAPS) and hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome of pregnancy. Available research projects focus on the study of complement gene variants in these and related thrombotic microangiopathies. This research will characterize new disease genes and pathways, develop molecular techniques to study disease mechanisms, and perform clinical assessment of disease phenotypes. All research projects involve next-generation sequencing of patient samples, analysis of sequencing data, and functional validation of candidate gene variants with correlation to clinical outcomes.  

The selected candidate will benefit from an excellent academic community, a thriving and multidisciplinary research environment, and a close interaction with the clinical teams. Postdocs will have many opportunities to attend major conferences, have a competitive salary, career development training and the ability to develop independent collaborations. Applicants should have a PhD or MD and be capable of managing their own projects as well as collaborating with other groups. A background in molecular biology is preferred. 

This is a temporary, full-time position of two years, with potential of extension, and is available immediately. Interested applicants should send a current CV to Evan Braunstein (ebrauns3@jhmi.edu) 

For more information, please visit: https://www.braunstein.team/ 

Description: A postdoctoral fellow position is available in the Department of Anesthesiology and Critical Care Medicine at Johns Hopkins University School of Medicine. We are looking for qualified persons with interest and experience in working with animal models, to join a multidisciplinary group working in the cutting-edge area of exploring noninvasive imaging, host-directed therapy and nanoparticles to optimize treatment in a pediatric rabbit model of tuberculous meningitis. This work is part of funded projects (NIH and Hartwell Foundation) to optimize tuberculous meningitis treatment using mass spectrometry, novel positron emission tomography (PET) radiotracers, anti-tubercular treatment and host-directed therapy in the rabbit model of tuberculous meningitis. As a postdoctoral fellow, the candidate will develop an Individual Development Plan (IDP) and receive career mentorship from a scholarship oversight committee that will meet regularly. The postdoctoral fellow will be eligible to apply for fellowship grants, and have access to departmental and institutional career development programs, such as grant writing workshops.

The candidate should have an interest in immunology/neuroscience, infectious disease pathogenesis (Tuberculosis), pharmacokinetics, nanoparticle drug delivery or other related fields. Research experience in any of these areas are highly desired but not required: (1) processing and handling of brain tissue, (2) tissue sectioning and immunohistochemistry, (3) basic microscopy or confocal imaging, (4) RT-PCR/Western Blots/ELISAs, (5) animal handling and behavior evaluation, (6) bacterial handling and culture, (7) flow cytometry, (8) pharmacokinetic basics, or (9) proficiency with statistical software. The candidate should be highly motivated, with good communication and writing skills and should be able to interact well with other members of the multidisciplinary team. The position is available immediately and salary will be commensurate with experience. Please submit your CV as well as a statement of interest with long-term career plans.

Contact Information:

Interested candidates are encouraged to contact:
Elizabeth Tucker, MD,
Assistant Professor
Anesthesiology and Critical Care Medicine
Johns Hopkins University SOM
Email: etucker9@jhmi.edu

JHU is an equal opportunity employer. Applications from minorities and women are especially encouraged.

We are recruiting three Physician Scientists and/or Postdoctoral Fellows to participate in “National Career Development Consortium for Excellence in Glycosciences” training at the Johns Hopkins University School of Medicine or Cleveland Clinic (https://glycocareers.cclinic.jhu.edu/). The objective of this nationwide program is to invest in the career development of the next generation of “glycoscience literate” biomedical investigators. This fellowship will provide scholars with an unparalleled opportunity to participate in cross-disciplinary research, obtain advanced knowledge, skills, and professional exposure within the glycosciencs, as well as to develop a research portfolio from which to launch independent careers. Scholars (M.D., M.D.-Ph.D., or Ph.D.) will be funded for two years to work on projects that focus on studying the roles of glycans in the pathophysiology of diseases relevant to the mission of the National Heart Lung and Blood Institute. The professional development of scholars and cross-disciplinary training is supported by a co-mentorship structure.

Projects will be broadly related to: Firstly) the role of O-GlcNAc in injury and in the pathophysiology of disease; Secondly) Immune regulation in airway diseases; Thirdly) Scholars already at Johns Hopkins can propose their own “Glyco-related project”.

Potential scholars should contact Natasha Zachara (nzachara@jhmi.edu) or Ronald Schnaar (Schnaar@jhu.edu) to explore potential projects and co-mentors.

Application process: Once projects are formulated scholars will submit an NIH style biosketch and statement of interest in PDF format to the admissions committee (GlycoED@jhmi.edu) no later than February 1st. The statement of interest should include a brief overview of the proposed project (based on discussion with Drs. Zachara and/or Schnaar), as well as a summary of the scholar’s long term career objectives (Arial 11 point, ½ inch margins, no less than single spacing). Additionally, scholars should have two letters of recommendation forwarded to the same email address.

Benefits: Salary support appropriate with position of up to $100,000 per year (inclusive of benefits), research supplies ($25,000), and travel/training will be provided. Rigorous training in the Glycosciences (didactic and technical) will be provided, as well as opportunities for professional development.

Eligibility: Scholars must be citizens or non-citizen nationals of the United States or have been lawfully admitted for permanent residence at the time of appointment. At the time of appointment scholars should hold an M.D. and/or Ph.D. degree.

Commitment: Scholars are expected to devote a minimum of 9 person months per year during their appointment. In addition to pursuing a research project in the glycosciences related to heart, lung, blood or sleep disorders, scholars must participate fully in the training opportunities provided by this award. We anticipate that the time commitment to training will be ~2 weeks per year. Progress will be reviewed annually, and funding will continue for up to two years as long as scholars remain in good standing.

The Johns Hopkins University is looking for a Postdoctoral Fellow (3 years duration) to assist with community engagement and research development within the recently launched University of California-Johns Hopkins University (UCSF-JHU) Opioid Industry Documents Archive. Fellows will take up their positions on July 1, 2022.

The UCSF-JHU Opioid Industry Documents Archive (OIDA), established in Spring 2021, is a digital collection of publicly disclosed opioid litigation materials. The Archive contains emails, memos, presentations, sales reports, training materials, budgets, audit reports, meeting agendas and minutes, expert witness reports, and depositions of pharmaceutical industry executives. The Archive provides a freely accessible digital resource for use by researchers, journalists, policymakers, and the public. The Archive provides an unparalleled opportunity to investigate scientific, legal, regulatory, and marketing questions, and apply computational as well as other diverse analytic methods, to generate fundamental new knowledge about the origins of the epidemic, and to inform changes to policies and practice to prevent future harms.

The CLIR/OIDA Postdoctoral Fellow will pursue original, publishable research using materials housed in the Archive and work closely with the Archive research team to enhance the accessibility and usability of archival materials for a diverse array of research communities. This will involve developing discovery tools and curating subject guides and other thematic “on-ramps” for potential users of OIDA data.  The fellows will take a leadership role in developing an effective organizational structure of the large volume of diverse materials housed in the Archive to facilitate a wide range of multi-disciplinary research endeavors. As part of their responsibilities, fellows will oversee research assistants charged with specific organizational and research tasks. Fellows will be mentored by and work closely with researchers and information specialists leading this work at JHU.  Fellows will be based at Johns Hopkins University, localized to the Baltimore area, housed at the Johns Hopkins School of Nursing or the Johns Hopkins School of Medicine and will be affiliated with the Center for Medical Humanities and Social Medicine and the Institute of the History of Medicine.

Position Start Date: July 1, 2022

Position End Date: June 30, 2025

Qualifications

Fellows should be well-versed in the history and social context of the ongoing harms associated with opioid overuse—which has become known as the “opioid epidemic” in the US, and/or be knowledgeable about research in related areas, such as the history, regulation, and impact of the pharmaceutical, tobacco, or food industries; agnotology; and the commercial determinants of health. We especially welcome applicants with training in social inequities, racism, perspectives on intersecting identities and society and political economy. Scholars with relevant prior publications and/or dissertation research are encouraged to apply. Fellows should also be familiar with methods in digital and computational humanities, and means of using digital platforms to build research communities and enhance dissemination and engagement. Fellows should be innovative scholars with excellent research, communication, and organizational skills; be comfortable working on  multiple projects in a dynamic  research setting; and have interest in helping work with many parties to build an important and accessible field of research.

Applicants with doctoral degrees in areas such as anthropology, sociology, history, history of medicine, information studies, political science, public health, health policy, nursing, American studies, and related fields with experience or interest in the digital humanities are eligible to apply. Dual degree trained scholars and health care providers, and interdisciplinary scholars are welcome.

Application Instructions

Apply to the CLIR Postdoctoral Fellowship Program to be considered for this position: https://postdoc.clir.org/join/

Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria. The University promotes Affirmative Action for minorities, women, individuals who are disabled, and veterans. Johns Hopkins University is a drug-free, smoke-free workplace.

Salary and benefits details are available here: https://www.hopkinsmedicine.org/som/offices/pda/policies.html

Questions about this position can be addressed to Cecilia Tomori at ctomori1@jh.edu

Questions about the CLIR Postdoctoral Fellowship Program and application process can be addressed to postdoc@clir.org.

Equal Employment Opportunity Statement

The Johns Hopkins University is committed to equal opportunity for its faculty, staff, and students. To that end, the university does not discriminate on the basis of sex, gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status or other legally protected characteristic. The university is committed to providing qualified individuals access to all academic and employment programs, benefits and activities on the basis of demonstrated ability, performance and merit without regard to personal factors that are irrelevant to the program involved.

The Department of the History of Medicine and the Center for Medical Humanities and Social Medicine (CMHSM), Johns Hopkins University, seeks applicants for a two-year postdoctoral fellowship in history of medicine and medical humanities.  The fellow will have teaching and administrative responsibilities in the department’s online program in the history of medicine (OPHOM) which offers Certificate and MA degrees to part-time learners. The CMHSM is an interdisciplinary teaching and research unit that bridges the humanities, social sciences, and health sciences across the campuses of Johns Hopkins University to foster innovative, interdisciplinary scholarship and to train undergraduates, graduate students, and health professionals with skills to apply critical social analysis to the understanding of health and disease.

 Duties include:

• Pedagogical and administrative support for OPHOM courses, including lecturing, facilitating class discussions, and grading.
• Liaising with OPHOM faculty members, administrators and instructional designers.
• Mentoring OPHOM Certificate and MA students.
• Organizing CMHSM events.
• Working with the CMHSM Director and faculty to develop new programs
• Liaising with CMHSM faculty and trainees across multiple campuses of Johns Hopkins University.
• Developing content for OPHOM and CMHSM online and social media presence.
• The fellow will have protected time to pursue a sustained program of research and writing, mentored by Department and CMHSM faculty, and is expected to make progress towards publication goals.

The term of appointment is two years, beginning July 1, 2022. Salary: $53,760 plus benefits.

Qualifications:

The successful candidate will have:

• Defended a PhD in history of medicine or related field by May 31, 2022.
• A proven record of scholarship and teaching in the history of medicine, humanities and/or social sciences of health and medicine.
• Previous interactions with health science as well as arts and science campuses
• A strong research profile.
• Excellent organizational skills.

Application Instructions:

Applicants should submit a cover letter, C.V., sample syllabus, and dissertation chapter or other writing sample via Interfolio submission (Application link: https://apply.interfolio.com/102154). Applications and related materials are due by Friday, March 18, 2022. Short-listed applicants will be requested to provide two letters of recommendation. Zoom interviews will be conducted in early April.

Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria. The University promotes Affirmative Action for minorities, women, individuals who are disabled, and veterans. Johns Hopkins University is a drug-free, smoke-free workplace. NOTE: The successful candidate for this position will be subject to a routine background check.

Salary and benefits details are available here: https://www.hopkinsmedicine.org/som/offices/pda/policies.html

The Toska lab in the Department of Oncology at Johns Hopkins University School of Medicine is seeking for highly motivated, talented and enthusiastic candidates for a fully funded postdoctoral position starting January 2022.

Our lab’s research focus is centered on elucidating the role that transcriptional and epigenetic regulators play in normal and cancer development, and therapeutic response in breast cancer. We are passionate about asking clinically relevant questions and translating basic laboratory findings into therapeutic applications to benefit cancer patients while at the same time providing new insights into the fundamental mechanisms of how epigenetic regulators regulate transcription and dictate cell identity. To achieve these goals, the Toska Lab undertakes a multidisciplinary approach integrating biochemistry, cell signaling, genomics and epigenomics at bulk and single cell level, organoid technology, and mouse genetics to study the fundamental processes by which epigenetic regulators regulate transcription, cross-talk with signaling pathways, and have the ability to drive transformation and dictate therapeutic response in nuclear receptor-dependent cancers.

Candidates must hold a Ph.D or M.D/Ph.D degree. Research background in biochemistry, molecular biology, or cell biology is preferred. Successful candidates will have access to state-of-the-art technologies in epigenomics, biochemistry, and in vivo models in a dynamic academic environment. Interested applicants should submit a CV and a brief description of their past work to etoska1@jhmi.edu.

Postdoctoral positions are available at Johns Hopkins School of Medicine - Johns Hopkins All Children’s Hospital in the fields of immuno-oncology and vascular biology. Prospective candidates will be investigating the tumor immune environment – in particular, tertiary lymphoid structure (TLS)-associated high endothelial venules and their role in anti-tumor immunity and immunotherapy in adult and pediatric cancers. An additional position is available to study the mechanism of maturation and stabilization of regenerating vasculature.

Ideal candidates have expertise in immunology, cancer biology, or vascular biology. Candidates must be highly self-motivated, independent individuals with Ph.D. or M.D. and hold publication records in one or more of the relevant areas. Visit our website for the research focus of the laboratory.

https://www.hopkinsmedicine.org/profiles/details/masanobu-komatsu

A recent publication from the lab in this area of research: https://pubmed.ncbi.nlm.nih.gov/35201289/

Interested applicants should submit a single PDF file containing a CV and a brief description of research interests and accomplishments to:

Masanobu Komatsu, Ph.D.
Associate Professor
Johns Hopkins All Children’s Hospital
mkomats1@jhmi.edu

Description: The Department of Biomedical Engineering and Institute for NanoBioTechnology at the Johns Hopkins University have an immediate opening for a highly-qualified postdoctoral scholar for research projects related to epigenetic-based cancer diagnostics incorporating novel microfluidic devices. The individual will be responsible for applying methylation microarray and next-generation sequencing methods towards identifying epigenetic biomarkers of early-stage cancers and developing targeted assays amenable to implementation in custom microfluidic devices. The successful applicant will join a world-renowned, highly interdisciplinary team of scientists, engineers and medical researchers with the goal of developing low-cost solutions for the noninvasive detection of multiple cancer types.

Required Qualifications:

• Ph.D. in a biomedical discipline, such as: biology, molecular biology, genetics, biomedical engineering, or other related field
• Experience in assay development and/or next-generation sequencing required
• Experience in epigenetics and/or the use or development of microfluidic devices preferred
• Experience/understanding of handling/analyzing genomics data and related bioinformatics will be an advantage
• A productive research history as evidenced by publication in peer-reviewed journals
• Ability to work both independently as well as part of a team.
• Excellent verbal and written communication skills

For consideration, please send a CV and one to three representative publications to Dr. Tza-Huei (Jeff) Wang and Dr. Thomas Pisanic at epidiagnostics@jh.edu.

The Johns Hopkins University is an EEO/AA Employer. The Department of Biomedical Engineering and Institute for NanoBioTechnology are committed to building a diverse educational environment, and women and minorities are strongly encouraged to apply.

Brady Urological Institute at Johns Hopkins University School of Medicine is recruiting a highly motivated candidate for a full-time postdoctoral research fellow position. successful candidate will lead studies on the role of coding and non-coding genes in the development of castration-resistant prostate cancer. This position will be within the laboratory of Shawn Lupold, the Catherine Iola and J Smith Michael distinguished professor of urology. Candidates will be working in a highly collaborative academic research community with a strong history of training, mentorship, and collaborative translational prostate cancer research.

As a Research Postdoctoral Fellow, you will manage a complex research project studying the molecular mechanisms of castration resistance in prostate cancer. These studies will include the planning, design, and execution of molecular and cancer cellular biology experiments, data recording, and data analysis. Experimental procedures include cell culture, plasmid and siRNA transfection, lentiviral transduction, CRISPR/Cas genetic editing, cell viability, apoptosis, migration, and invasion assays, qRT-PCR, and western blotting. The individual will coordinate, organize, and document research findings. Research progress and results will be presented at laboratory and institutional meetings, as well as at national and/or international scientific meetings. The individual will work with the team to prepare, write, and submit scientific manuscripts and grants. The Lupold laboratory and the Brady Urological Institute are dedicated to fellow training, growth and success within a friendly team science cancer research environment.

This position requires a Ph.D. and/or M.D. in a related discipline, and a strong background in molecular biology, and 0-3 years of postdoctoral research experience. Applicants with experience in cancer molecular biology, prostate cancer research, and/or CRISPR gene editing will receive top priority.

Interested applicants should contact Shawn Lupold: slupold@jhmi.edu

Employer Name: Johns Hopkins University School of Medicine, Department of Urology

Position location: Baltimore, Maryland

Application Deadline Date: June 30^th, 2022

(PI: Dr. Jun Luo)

Johns Hopkins University, Department of Urology

The Luo lab at the Johns Hopkins University is seeking an independent and motivated postdoctoral fellow to study non-coding, circular RNA in prostate cancer. Toward this end, we combine molecular biology, cell biology, and computational biology. The postdoctoral fellow will focus on the identification of circular RNAs in prostate cancer, and how the associated functional consequences of circular RNAs contribute to cancer development. Candidates will ideally have interests relevant to these topics, and will have opportunities to pursue their own research interests in prostate tumorigenesis.

Our lab is part of the Brady Urological Institute, Department of Urology at Johns Hopkins University School of Medicine.

The successful candidates will have a Ph.D. in the following or related fields: cancer biology, molecular biology, biochemistry, genetics, epigenetics, cell biology, bioinformatics or computational biology. We are currently looking for a candidate who (1) have extensive experience with molecular and cellular biology, and (2) have experience with -omics data and strong quantitative skills will be a plus. Good organizational and writing skills are also required.

The position is DOD-funded. Salary will depend on candidate experience. The start date is flexible and can be as early as July 2022.

To apply, email the following to Jun Luo (jluo2@jhmi.edu) with the subject line “Postdoc application”:

[Your full name].

– curriculum vitae, including a full list of publications. Pre-print articles can be included.

– a short (one-page maximum) statement describing candidates’ past research experience, why you want to join us, future research interests, and you as a person

– contact information for three references

Please contact Dr. Jun Luo (jluo2@jhmi.edu) for any questions. Informal inquiries are welcome.

The Johns Hopkins University is an Equal Opportunity/Affirmative Action Employer advancing inclusive excellence. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, disability, age, protected veteran status, or other protected categories covered by the JHU nondiscrimination policy.

Johns Hopkins University School of Medicine
Baltimore, Maryland, US
Posted: 25 July 2022

Are you interested in research that is directly influenced by clinically important questions?
A postdoctoral position is available immediately, in the Jeff Dodd-o Laboratory in the Department of Anesthesiology and Critical Care Medicine at the Johns Hopkins University School of Medicine. We work closely with the Division of Pulmonary and Critical Care Medicine, as well as with transplant surgeons, to better understand the immunology of transplant rejection. Our overarching goal is to improve upon the efficacy of immunosuppression while reducing the debilitating side effects. The position will provide exposure and mentorship in the evaluation of immunoregulation through the use of lung injury and transplant models, flow cytometry, RNA and protein analysis

Job description:
A full-time Research Specialist position is available immediately in the laboratory of Jeffrey M Dodd-o, MD, PhD (https://anesthesiology.hopkinsmedicine.org/ ) in the Department of Anesthesiology and Critical Care Medicine at Johns Hopkins University. Our group studies the immunology of lung transplantation using both a novel murine lung ischemia:reperfusion model developed in the lab, as well as a murine, in-situ lung transplant model. We study the innate and adaptive immunity mechanisms leading to transplant rejection, with the goal of interrupting or preventing rejection completely. We have developed pharmacologic and chimeric methods, with our goal being a better understanding of the complete mechanistic pathways responsible for their success. The technology we use includes flow cytometry, CT scan, single cell RNA, and adoptive cell transfer.

Key requirements:
The candidate will conduct impactful physiologic experiments in a preclinical Murine model. All protocols follow AALAC guidelines. Techniques include delivering anesthesia, performing tracheal intubation, harvesting transplanted lungs, creating single cell suspensions, running and interpreting flow cytometry, western blots and immunoprecipitation, and biochemical assays (spectrophotometric, fluorogenic, luminescence). Cell harvesting for adoptive transfer, cell culturing, and developing new panels as well as assays of cytotoxic cell function are also part of our research protocol.

The responsibilities will include working alone as well as with collaborating research teams to conduct the murine ischemia;reperfusion surgeries, post-operative care of transplanted lung recipients, lung/spleen/bone marrow harvesting for the creation of single cell suspensions to be used in flow cytometry, adoptive cell transfer and cell culturing. You will work with the PI and collaborators to create new protocols evaluating cell cytokine production as well as panels for flow cytometry. Additional duties include running flow cytometry, its data entry and analysis, as well as animal feeding, cage clean-up and sanitation, and general laboratory organization.

Good oral communication skills in English and a collaborative and cooperative team spirit are required. Team work is essential in our laboratory. High priority candidates need to have, at a minimum, experience with in vitro work with human or animal cells and/or flow cytometry. Applicants with interest in immunology are encouraged to apply. An MD and/or PhD degree is required. Other helpful experience would be in cell culturing, immunohistochemistry, protein and DNA methods, microscopy (conventional and confocal), cell counting skills, and data processing.

The work schedule is flexible, although collaborations are often best performed between 9 a.m. and 5 p.m.. Only very infrequent weekend stop-ins for animal care will be requested.

Employment at Johns Hopkins University:
The employment is a 2-year position with a possibility of prolongation. A 6-month trial period will be applied. Postdoctoral fellow salary will be based on NIH guideline, individual health insurance [through the School of Medicine Student Health Program (SHP)] and dental insurance will be provided. Salary is commensurate with skills and experience and benefits will be provided.

Apply:
Interested candidates should submit a single document containing: 1) an updated CV (including date of the thesis defense, title of the thesis, previous academic/work positions, academic title, current position, academic distinctions and list of peer-reviewed publications), 2) a brief personal statement describing research interests and career goals, and 3) contact information for three references. Select applicants will be invited to interview. Please directly email the document to:

Dr. Jeffrey M Dodd-o, M.D., PhD
jdoddo@jhmi.edu
Associate Professor, Department of Anesthesiology
Department of Anesthesiology and Critical Care Medicine
Johns Hopkins University-School of Medicine
Baltimore, Maryland 21218

Johns Hopkins University is an equal opportunity employer M/F/D/V.

A postdoctoral fellow position is currently open in Dr. Rui Zhou’s laboratory in the Departments of Medicine, Biological Chemistry and Oncology, Johns Hopkins University School of Medicine and Center for RNA Biology, Johns Hopkins All Children’s Hospital. The Zhou laboratory is employing a combination of biochemical, genetic, genomic and functional genomic approaches to study the molecular mechanism governing the biogenesis of regulatory non-coding RNAs, and to elucidate their function in innate immunity, neuro-development, metabolism and tumor formation.

We have identified and characterized key regulators of RNA interference and antiviral defense (Zhou et al, Molecular Cell, 2008; Sabin, Zhou et al, Cell, 2009; Czech & Zhou et al, Molecular Cell, 2009; Ni, Zhou & Czech et al, Nature Methods, 2011; Xiong et al, PNAS, 2013; Lim et al, RNA Biology, 2014; Xiong et al, PLoS Genetics, 2015; Molleston et al, Genes & Development, 2016). In addition, we have established microRNA-34 as a crucial modulator of innate immunity and steroid hormone signaling (Xiong et al, PLoS Pathogens, 2016). Furthermore, we have identified a group of circular RNAs that impact innate immunity and neuro-development (Liu et al, PLoS Genetics, in revision; Xiong et al, PLoS Genetics, in revision). Moreover, in collaboration with the Perera lab, we are studying the function of circular RNAs in medulloblastoma (Pokhrel et al, Neuro-Oncology, in revision). Lastly, we are investigating the function and regulation of circular RNAs in lipid metabolism and antiviral immunity (Liu et al, in preparation; Liang et al, in preparation). Ongoing work focuses on elucidating the underlying molecular mechanism using both animal models (Drosophila and mice) and cultured (Drosophila and mammalian) cells. We seek a postdoctoral fellow to drive these exciting projects forward.

Required skills: The preferred candidate should have a strong background in the following areas: biochemistry, molecular biology, and Drosophila genetics, and should be highly motivated, and superb at both bench work and critical thinking.

This position is expected to start immediately, and will be based at the Center for RNA Biology, Johns Hopkins All Children’s Hospital in St. Petersburg, Florida, which is known for its pleasant weather, low cost of living, and beautiful beaches. Salary and fringe benefits will be compliant with guidelines established by the Johns Hopkins University School of Medicine. The Zhou Lab is located in the newly completed 225,000-square-foot state-of-the-art Research & Education Building. We enjoy interactions with a vibrant and collegial group of Departmental colleagues working on RNA Biology, gene regulation, vascular biology, immunology, oncology and metabolism. Interested candidates please send CV and relevant publications to Dr. Rui Zhou: rzhou13@jhmi.edu.

Supervisor: Nicolas J. Llosa, MD

Nicolas J. Llosa's Research: https://www.researchgate.net/scientificcontributions/Nicolas-J-Llosa-2057408066

General Description:
A Research Postdoctoral Fellowship position is offered in the Cancer Immunology Program at Johns Hopkins University School of Medicine under the mentorship of Dr. Nicolas J. Llosa. The Laboratory of Cancer Immunology functions as a multidisciplinary and interdisciplinary basic and translational research programmatic effort with the goal of developing novel immunotherapies for cancer. Our lab strategic plan focuses on the development of novel immunotherapeutics for patients affected with sarcoma, not only as monotherapies, but more importantly, in combination with other immune mediating modalities, and other conventional or experimental therapies, as part of an immuno-oncology programmatic effort. Our program is seeking an ambitious and highly motivated person to lead studies focused on elucidating the mechanisms of immune evasion and immune regulation in sarcoma. The work will involve studies in human sarcoma tissues and modeling studies in mice with the use of latest tools, such as high-dimensional flow cytometry, multiplex immunohistochemistry/immunofluorescence of tissues, immunometabolism interrogations, scRNA-seq, ATAC-seq, and generation of novel recombinant proteins. The Research Postdoctoral Fellow will be responsible for the conceptualization, design, and statistical analyses of research studies in the field of sarcomas immunobiology, as well as the drafting of these studies academic manuscripts.

Qualifications:
Applicants must have a PhD. and /or M.D. degree (or anticipate receiving their degree in the near future) with less than five years of postdoctoral experience. Applicants should have the ability to carry out independent research, a strong interest in interdisciplinary approaches and have published articles in peer-reviewed journals. Training in molecular biology, immunology, biochemistry, oncology and bioinformatics is preferred.

How to apply:
Please send CV and cover letter outlining your experience and interests to Nicolas J. Llosa: nllosa1@jhmi.edu

Position is full-time, 8 hours, five days a week in the Dept. of Anesthesiology, JHU School of Medicine. Salary: commensurate with experience ($52,000 -$57,000)

General Summary/Purpose: This is a new position for research Post-Doctoral Research Fellow who will be funded from a new NINDS grant. They will acquire and analyze the MRI data from up to 630 new MRI images including gadolinium derived images of blood brain permeability, regional blood flow as well as other DTI, FLAIR, and T1 based imaging of white matter lesions obtained from asymptomatic healthy participants at risk for vascular changes and associated cognitive changes. They will work with Dr. Paul Nyquist, Dr Peter Van Zijl, and Dr Linda Knutsson working at the department of Anesthesia at the Johns Hopkins University and the FM Kirby Research center in the Kennedy Krieger Institute. They will also be responsible for acquisition, analysis, and management of the imaging dataset of this study. They will be an integral partner in the new NINDS grant entitled : “Vascular Contributors to Blood Brain Barrier Permeability and Regional White Matter Hyperintensity Progression in Young Asymptomatic People”. In addition there will be opportunities to work with leaders in the MRI and anesthesiology fields and work on related projects and develop an independent career in academics.

Specific duties & responsibilities: To acquire, analyze, and manage the imaging database for the study entitled “Vascular Contributors to Blood Brain Barrier Permeability and Regional White Matter Hyperintensity Progression in Young Asymptomatic People”.

Minimum qualifications (mandatory): PhD

Preferred qualifications: Experience in Biomedical Engineering or MRI imaging with interest in medical MRI applications

Special knowledge, skills, and abilities: Preferably experience in MRI methods and analysis of MRI images. Willingness to work with scientists and clinicians with multiple backgrounds.

Technical qualifications or specialized certifications: none

Any specific physical requirements for the job: none

Supervisory responsibility (indicate the number and type of persons supervised by incumbent): none

Budget authority (indicate dollar amount of budget managed and type/level of authority): None

Prepared by: Paul Nyquist

Date: 08/05/22

Dr. Moonjung Jung’s laboratory at Johns Hopkins University School of Medicine in Baltimore, MD is seeking a highly motivated postdoctoral fellow who is interested in hematopoiesis, aging, and DNA repair research.

A successful candidate is expected to have experience in human and/or mouse hematopoiesis, molecular biology, cell biology, and aging research. A postdoctoral fellow will conduct the research to study the relationship between DNA damage and alcohol use, and their contribution to hematopoietic stem cell (HSC) aging.

Our laboratory studies endogenous and exogenous sources of DNA damage, how they cause DNA damage in HSC, and how such DNA damage in HSC leads to bone marrow failure. We are using Fanconi anemia, the most common inherited bone marrow failure syndrome due to DNA repair defects, as well as alcohol use as model diseases to ask these fundamental questions.

We provide training opportunities in cutting-edge technologies such as functional CRISPR screens and single-cell RNA-sequencing. We also provide a fun, dynamic, and inclusive training environment in the Division of Hematology, Department of Medicine at Johns Hopkins University School of Medicine, with outstanding opportunities for collaboration and co-mentorship (http://jung-lab.org). Interested candidates should contact Dr. Moonjung Jung at mjung@jhmi.edu with a curriculum vitae, cover letter, and a list of three references.

Qualification: Ph.D. in the field of cell biology, molecular biology, or related fields within the last 2 years.
Application deadline: open until the position is filled.

Opportunity to lead an exciting project in an R01-funded lab to elucidate the role of donor-derived immune cells in the development of graft-versus-host disease and non-infectious lung injury following allogeneic bone marrow transplantation using established mouse models. The candidate will be responsible for conducting the research and coordinating the full range of project’s cellular and molecular components. This will include but not necessarily be limited to: managing the 1) bone-marrow process from stem cell harvesting through transplantation, 2) tissue and cell procurement, processing and analysis, 3) data interpretation and presentation; and ultimately, 4) training of project-associated research personnel. The candidate should have an MD and/or PhD, with at least 3-5 years of lab experience in immunology or pulmonary biology. Proficiency in working with pulmonary immune, endothelial and epithelial cells along with flow cytometric analysis are of particular interest. Salary negotiable, within established University guidelines.

How to apply:
Please send CV and cover letter outlining your experience and interests to Ken Cooke: kcooke5@jhmi.edu. 

A funded position is available to work on an innovative CANCER IMMUNOTHERAPY utilizing myeloid cells genetically programmed to generate pro-inflammatory tumor and lymph node macrophages and dendritic cells. This novel cell therapy has already proven successful in several murine models of cancer, and we now seek to further understand the mechanisms underlying slowing of tumor growth and to develop approaches for obtaining even stronger responses. Experience with cancer biology, immunology, molecular biology, and/or bioinformatics would be valuable.

Please submit a CV and names and contact information (email and phone numbers) for references to:
Alan D. Friedman, M.D., Professor, Pediatric Oncology
Johns Hopkins University School of Medicine
Cancer Research Building I, Room 253
1650 Orleans Street, Baltimore, MD 21231
E-mail: afriedm2@jhmi.edu

Macrophages can adopt a pro-inflammatory M1 phenotype capable of activating T cells to suppress tumor growth or, alternatively, a tumor-promoting M2 phenotype that inhibits T cell activation. NF-kB is a transcription factor favoring M1 gene expression. Multiple solid tumors grow slower in mice lacking the repressive NF-kB p50 subunit (e.g. Barberi T… Friedman AD. Cancer Immunol. Immunoth. 2018). To develop a way to translate these findings to patients that avoids also activating NF-kB in cancer cells, we conducted experiments in which we isolate immature myeloid cells from the bone marrow of mice lacking NF-kB p50; we find that intravenous injection of these cells, termed p50-IMC, slows the growth of prostate cancer, pancreatic cancer, neuroblastoma, and glioblastoma by increasing the number of activated tumor T cells (Suresh R… Friedman AD. J. Immunoth. Cancer 2020; Cui C… Friedman AD. Molec. Oncol. 2021; and unpublished).

Now we are pursuing efforts to further improve efficacy of murine p50-IMC in immune-competent mouse tumor models, e.g. by adding expression of chimeric antigen receptors (CARs) via viral transduction, which may favor p50-IMC tumor localization and may enhance phagocytosis of tumor cells and thereby antigen presentation, or by using CRISPR/Cas9 to edit additional genes in p50-IMC expected to further favor T cell activation. In addition, we are developing human p50-IMC for clinical application. The new post-doctoral fellow would contribute to these efforts while also helping us further characterize the cells that develop in vivo from p50-IMC and the gene expression changes present in these cells, e.g. using multi-parameter flow cytometry and immuno-histology, RNA-seq, ChIP-Seq, and ATAC-Seq.

The laboratory, located on the medical campus of Johns Hopkins University in the modern Cancer Research Building I, currently has one Research Associate and two post-doctoral fellows and employs cell culture, murine models, and methods of modern molecular and cell biology. I have had ongoing grant funding and have trained more than 30 graduate students and postdocs over the past 33 years. Many neighboring laboratories in the Cancer Center pursue related projects in cancer therapy, providing frequent opportunities for interaction, and excellent seminars in cancer biology occur frequently. The atmosphere in the laboratory is very friendly and supportive, and I as the PI often work in the laboratory and have frequent conversations with my lab members.

Johns Hopkins University is an equal opportunity employer and does not discriminate on the basis of gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status, other legally protected characteristics or any other occupationally irrelevant criteria. The University promotes Affirmative Action for minorities, women, individuals who are disabled, and veterans. Johns Hopkins University is a drug-free, smoke-free workplace.

The Medicine, Science, and the Humanities Program (MSH), Johns Hopkins University, seeks applicants for a two-year postdoctoral fellowship in the history of science, technology or medicine, science and technology studies, or other related or allied fields.

The fellow will have teaching and administrative responsibilities in the new Critical Approaches to Science, Technology, and Medicine Masters (CAST-M) track–a new two-year academic MA track designed to support students from traditionally marginalized backgrounds to join and succeed in academia. The fellow will also teach one undergraduate course every semester at MSH program–the largest humanities major at Johns Hopkins University. MSH is an interdisciplinary, humanities-based major that provides students with a cross-disciplinary understanding of the cultural and historical roots of scientific and medical inquiry, knowledge, and practice. CAST-M is a new two-year MA track meant to encourage graduate student diversity in the fields of science studies, medical humanities, history of science and technology, and history of medicine. We aim to recruit and support emerging scholars from backgrounds that are traditionally marginalized in STEM-adjacent humanities fields. This position is affiliated with the Institute for the History of Medicine and the Center for Medical Humanities and Social Medicine at Johns Hopkins School of Medicine.

Duties include:

• Pedagogical and administrative support for the CAST-M program, including teaching, following students’ progress, leading discussions and convening events, co-advising and grading student MA theses.
• Participating in the publicity for CAST-M and the recruitment of CAST-M students (starting from the second cohort). This includes supporting the Director of Graduate Studies and administrative staff in arranging prospective student virtual visits, managing applications, and creating shortlists, among other related duties
• With support from an assigned faculty member, convene the CAST-M proseminar, which brings together faculty and CAST-M students to discuss various questions related to academic professionalization.
• Teach one undergraduate course each semester in the MSH program.

The fellow will be an active member of the MSH and History of Science, Technology, and Medicine community at Johns Hopkins University. The fellow will have protected time to pursue a sustained program of research and writing and will be assigned a faculty mentor to support their work.

The term of appointment is two years renewable up to four years, beginning July 1, 2023. Salary: $60,000 plus benefits.

Qualifications

We welcome applications from candidates with a background in the history of medicine, science, and/or technology, science and technology studies, anthropology, sociology, art history, or any other discipline with a focus on science, technology, and medicine. Candidates studying the intersection of science, technology, and/or medicine with questions of race, gender, sexuality, colonialism, and marginalization, as well as those critically engaging with science, medicine, technology, and engineering in the Global South and in communities subject to systemic discrimination are especially welcome.

We particularly encourage applications from candidates from traditionally marginalized backgrounds and those with experience and knowledge of dealing with questions of diversity in the field.

The successful candidate will have defended a Ph.D. in history of medicine or a related field by May 31, 2023.

Application Instructions

Applicants should submit the following: 1) cover letter, 2) C.V., 3) sample syllabus for an undergraduate seminar on a theme of the candidate’s choosing, 4) dissertation chapter or other writing sample, and 5) statement on diversity and inclusion, where the applicant explains their views on how to further the CAST-M program goals, including, for example, how they plan to use the proseminar space to support the students and the program goals.

Applications are to be submitted via Interfolio. All applications and related materials are due by Friday, March 3, 2023. Short-listed applicants will be requested to provide two references who will be contacted by the search committee. Zoom interviews will be conducted in early April.

Application Process

This institution is using Interfolio's Faculty Search to conduct this search. Applicants to this position receive a free Dossier account and can send all application materials, including confidential letters of recommendation, free of charge.

Apply Now

Equal Employment Opportunity Statement

The Johns Hopkins University is committed to equal opportunity for its faculty, staff, and students. To that end, the university does not discriminate on the basis of sex, gender, marital status, pregnancy, race, color, ethnicity, national origin, age, disability, religion, sexual orientation, gender identity or expression, veteran status or other legally protected characteristic. The university is committed to providing qualified individuals access to all academic and employment programs, benefits and activities on the basis of demonstrated ability, performance and merit without regard to personal factors that are irrelevant to the program involved.

The Sena laboratory in the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins is looking for a post-doctoral fellow to join our group in studying how prostate cancer metabolism regulates disease progression, response to therapy, and tumor immunity. We are a highly collaborative group motivated by a unifying desire to improve therapies and outcomes for patients with prostate cancer. We use cell line and mouse models of prostate cancer to study mechanisms and patient specimens to assure translational relevance of our findings. Our goal is to translate our findings into clinical trials with informative correlative studies to maximize opportunities for successfully improving the lives of patients. We are committed to creating a warm, diverse, and collaborative environment to foster the highest level of scientific rigor and world-class training in translational research of cancer.

The post-doctoral researcher will be involved in all aspects of experimental design, data acquisition, and communication of results. They are expected to have a PhD in a relevant field, such as cancer research or immunology, with advanced skills in molecular biology and cell culture, experience working with mouse models, and a willingness to learn new techniques. They should love discovery, have strong skills in deductive reasoning, a desire to help patients, and be committed to supporting a friendly, inclusive, and collaborative environment. They should have a strong record of productivity and excellent communication skills. Experience in analysis of large datasets such as metabolomics, bulk and single cell RNA-seq and ATAC-seq, and high parameter flow cytometry is desirable. They can expect to take leadership of a project and receive personalized supervision, mentorship, and sponsorship by Dr. Sena. The laboratory is located within the Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins University, which will enable the post-doctoral fellow to interact and collaborate with top experts in the field of cancer research.

Specific Duties and Responsibilities:

• Lead projects with the assistance of Dr. Sena
• Apply molecular biology techniques (gene deletion, knock-down, overexpression, protein inhibition, cell type depletion) to interrogate molecular mechanisms (read-outs of cell viability and proliferation, tumor growth in mice, tumor immune infiltrate, protein abundance by western blot and flow cytometry, RNA abundance by RT-PCR and RNAseq, metabolite abundance by LC-MS).
• Understand rationale behind experiments and apply analytical skills to interpret data and determine next steps and troubleshooting.
• Open to learning new techniques and participate in training others in the lab

Requirements:

Education/Experience: PhD in relevant field

Skills: As above

Are you interested in research that is directly influenced by clinically important questions?

Chemotherapy-induced peripheral neuropathy (CIPN) is a common dose-limiting side effect of cancer treatment drugs that often presents as debilitating pain; we want to discover new cancer pain therapies using clinically-informed basic science approaches.

A postdoctoral position is available from August 1, 2021, in the Sivanesan Neuromodulation Laboratory (SNL) / Translational Pain Research Program in the Department of Anesthesiology and Critical Care Medicine at the Johns Hopkins University School of Medicine.

Dr. Eellan Sivanesan’s lab is embedded in a rich and dynamic scientific "village" encompassing related groups with expertise in somatosensory neuroscience, neuropharmacology, electrophysiology, cancer biology and the tumor microenvironment, and spinal cord stimulation stimulation. The lab is focused on developing new technology to treat cancer pain, cancer-related pain (e.g. chemotherapy-induced peripheral neuropathy), and other chronic pain disorders, and uncovering the neural mechanisms underlying the somatosensory, affective, and cognitive aspects of pain. The position will provide rigorous exposure and mentorship in interdisciplinary pain neuroscience research between the departments of anesthesiology, oncology, and neurological surgery with guidance towards a future career in academia or industry.

Job description:

We are seeking an ambitious and motivated postdoctoral candidate who is interested in research into cellular and molecular aspects of sensory physiology and pain. We investigate cancer-related pain conditions (particularly chemotherapy-induced peripheral neuropathy), cancer biology (particularly tumor environment), neuroimmunology, and electrical neuromodulation, and their functions in sensory transduction, conduction, and transmission under both physiological and pathological conditions. We employ multi-disciplinary approaches including immunohistochemistry, immunocytochemistry, molecular biology, light and confocal microscopy, electrophysiology, neuropharmacology, histology, calcium imaging, RNA sequencing, and animal behavioral assessment to conduct pain research. To translate our rodent discoveries, we partner with neurological surgeons, pain medicine physicians / anesthesiologists (invasive neuromodulation experts), and prominent basic scientists to study human neural tissue and human approved neuromodulation devices from patients living with chronic pain.

We bring together investigators from Departments across Johns Hopkins to collaboratively tackle basic science, translational, and clinical research problems relevant to pain, and operate within a broader multidisciplinary pain research community that includes weekly pain-focused journal clubs, weekly pain seminars, and funding programs to foster the career development of trainees and junior faculty in the pain field. We also benefit greatly from a strong scientific, translational, and clinical research environment at Johns Hopkins that spans numerous biomedical disciplines. Ample opportunities for career development, mentorship and clinical exposure based on candidate interest. 

Key requirements:

We are looking for a creative and highly motivated postdoctoral researcher with strong enthusiasm for science. A successful candidate should have a PhD degree within the last three years in the biomedical field and a strong academic background in neuroscience, molecular biology, electrophysiology, neurophysiology, pharmacology, cell biology, chronobiology, neuroimmunology, cancer biology (tumor microenvironment), or another related discipline. Applicants should have experience working with animals in a research environment.

At least one first author publication (peer reviewed original research) and previous experience with pain research are considered strong merits. The ideal candidate should be able to work independently and will take part in experimental planning, applying for grants, drafting of manuscripts and co-supervision of research staff and students. There will be opportunities to develop experimental tasks, analyze large datasets and to present and publish high impact science. Excellent communication skills in English, good interpersonal skills, and ability to work in team environments, and technical and organizational abilities are expected.

Employment at Johns Hopkins University:

The employment is a 2-year position with a possibility of prolongation. A 6-month trial period will be applied. Postdoctoral fellow salary will be based on NIH guideline, individual health insurance [through the School of Medicine Student Health Program (SHP)] and dental insurance will be provided. Salary is commensurate with skills and experience and benefits will be provided. 

Apply:

Interested candidates should submit a single document containing: 1) an updated CV (including date of the thesis defense, title of the thesis, previous academic/work positions, academic title, current position, academic distinctions and list of peer-reviewed publications), 2) a brief personal statement describing research interests and career goals, and 3) contact information for three references. Select applicants will be invited to interview. Please directly email the document to:

Dr. Eellan Sivanesan, M.D.
esivane1@jhmi.edu
Assistant Professor, Department of Anesthesiology
Director of Neuromodulation
Department of Anesthesiology and Critical Care Medicine
Johns Hopkins University-School of Medicine
Baltimore, Maryland 21218

Deadline: January 1, 2023.

Sivanesan Neuromodulation Laboratory (SNL) Website
Twitter: @DoctorSivaMD
LinkedIn: https://www.linkedin.com/in/eellan-sivanesan/

Johns Hopkins University is an equal opportunity employer M/F/D/V.

Johns Hopkins University School of Medicine
PI Roger A. Johns MD, PhD
Location The laboratory is located in the medical campus of Johns Hopkins University
Discipline Neuroscience
Position Type Full Time
Job Type Postdoctoral Fellow
Salary Open

POSTDOCTORAL POSITION available to study the role of postsynaptic scaffolding proteins (MAGUKs) in developmental neurotoxicity and long-term cognitive dysfunction. Focus is on the role of the PSD-95 family of MAGUK proteins and their downstream pathways in regulating synaptic development and function, mediating anesthetic sensitivity and neurotoxicity, and chronic pain. Critical skills include a strong technical expertise in biochemistry, imaging, rodent behavior, cellular and molecular biology. Helpful to have knowledge of MAGUK scaffolding protein function and experience in neurophysiology, fret imaging, protein-protein interaction, and dendritic spine analysis. Highly motivated PhDs with a strong publication record are encouraged to apply. 

Send application letter, CV and contact information for three references to Dr. Roger Johns (rajohns@jhmi.edu)

Johns Hopkins University School of Medicine
PI Roger A. Johns MD, PhD
Location The laboratory is located in the medical campus of Johns Hopkins University
Discipline Vascular Biology/Immunology
Position Type Full Time
Job Type Postdoctoral Fellow
Salary Open

POSTDOCTORAL POSITION available to study the immunology of vascular and cardiac remodeling and inflammation. The group focuses on the immunoregulation and immunotherapy of cardiovascular and pulmonary diseases and other lung inflammation-related pathology with a special interest in pulmonary hypertension, vascular and cardiac remodeling. The role of the resistin family of protein cytokines, the NLRP3 inflammasome and their downstream pathways are actively being pursued at multiple levels including cell and molecular biology, pathophysiology, biomarker and development of therapeutics. Critical skills include a strong technical expertise in biochemistry and molecular biology, imaging, in the context of vascular and immunobiology. Highly motivated PhDs with a strong publication record are encouraged to apply. 

Send application letter, CV and contact information of three references to Dr. Roger Johns (rajohns@jhmi.edu).

Join a multi-disciplinary group of translational scientists working at the cutting edge of nanomedicine for CNS disorders. Work on clinically relevant projects and animal models to see your science translate from the bench to the bedside.

The Kannan lab at Johns Hopkins School of Medicine is looking for motivated individuals who are interested in translational neuroscience and evaluating therapeutics for applications in neuroinflammatory and neurodegenerative disorders across the age spectrum working with pre-clinical models of neurologic injury during development and in adulthood. Extensive collaborations between engineering, the Center for Nanomedicine, critical care medicine, pediatrics, drug discovery and neurology/neuroscience are key components of the project

Responsibilities

• Evaluate novel nanotherapies min pre-clinical neuroinflammatory and neurodegenerative models of brain injury such as traumatic brain injury, neurodevelopmental disorders, chronic pain, PTSD, depression.
• Characterize glial responses to therapy using immunohistochemistry, FACS, transcriptomics, metabolomics
• Design, co-ordinate and lead multi-disciplinary projects
• Data analyses, presentations, manuscript writing
• Mentor students and technicians

Qualifications
The candidate must have completed or be in the process of completing a PhD in neuroscience/immunology/neuropharmacology or related fields. Research experience in these areas are highly desired: (1) neuroimmunology/evaluating inflammation and glial responses (2) macrophage/microglia isolation and primary cultures (3) FACS, evaluating microglial/macrophage phenotype (4) microscopy (confocal, fluorescence and/or 2-photon imaging) (5) Rodent behavior (6) EEG. Experience in MRI/DTI/PET imaging in animals, electrophysiology, gene editing techniques, bioinformatics (for single cell transcriptomics, metabolomics) would be an asset.

The candidate should be highly motivated, with excellent communication and writing skills and should be able to interact well with other members of the team.

Johns Hopkins University SOM is an equal opportunity employer and candidates with backgrounds underrepresented in STEM are strongly encouraged to apply.

Contact Information
Interested candidates are encouraged to contact:

Sujatha Kannan, MD,
Professor, Anesthesiology and Critical Care Medicine
Richard J Traystman Endowed Chair
Johns Hopkins University SOM
Email: skannan3@jh.edu
Website: https://anesthesiology.hopkinsmedicine.org/research-home/research-programs/kannan-neuroinflammation-and-nanomedicine-lab/

The Dalton lab in the Department of Hematologic Malignancies at the Johns Hopkins University School of Medicine is seeking candidates for NIH/R01-fully-funded postdoctoral positions starting as soon as March 2023.

The goals of our lab are 1) to understand how spliceosome mutations shape oncogenic—and interesting ‘passenger’—phenotypes in human cancer and 2) to develop therapeutic strategies to target spliceosome-mutant disease. To do this, we study engineered human cell models (immortalized cells, transformed cells, and induced pluripotent stem cells); primary patient tumor samples; human xenografts in immunodeficient mice; and correlative primary clinical data. Our emphasis is on myeloid neoplasms—MDS and AML, but our studies also have implications for other cancer types, as well as basic mechanisms of RNA splicing and cell biology. Current projects include deciphering how distinct SF3B1 mutations differentially affect RNA splicing and MDS phenotypes, characterizing downstream phenotypes and vulnerabilities of SRSF2 mutations, advancing therapies exploiting serine auxotrophy in SF3B1-mutant cancers, and developing immunotherapeutic modalities against spliceosome-mutant cancers.

You can visit Dr. Dalton’s bibliography here: https://scholar.google.com/citations?user=nDvqx_AAAAAJ&hl=en

Candidates must hold a PhD (or MD with at least 3 years independent research experience). We welcome applications from diverse backgrounds, but candidates with expertise in cancer cell biology, genetics, and metabolism are especially encouraged to apply.

Interested applicants should send the following materials in an application packet, preferably as a single PDF file, by email to Dr. Brian Dalton (wdalton2@jhmi.edu)

1. Cover letter indicating current and future research interests, as well as a brief summary of previous research experiences
2. Expected starting date
3. Curriculum vitae
4. Names and contact information for 3 references

The fellowship provides an annual salary commiserate with NIH guidelines for PGY level with full healthcare benefits. Postdoctoral scientists will be employees of Johns Hopkins University, an Equal Opportunity/Affirmative Action Employer. Applicants are not required to be United States citizens.

Genitourinary Oncology
Administrative Office
1650 Orleans St., CRB 1, Rm 1M42 Baltimore, Maryland 21231
410-502-6489 Phone
410-614-8397 Fax

February 2, 2023

Organization: Johns Hopkins University Job

Description: Multiple immediate postdoctoral positions are available for a fresh Ph.Ds. in cancer biology and proteomics, or related field. The candidate must have experience in molecular and cellular biology. Experience in bioinformatics and single cell transcriptomics or proteomics is desired. The lab works on prostate cancer with special focus on androgen signaling, DNA repair, cancer invasion, and metastasis. Highly motivated candidates who can independently drive research projects, willing to write research grants, and work in a collaborative environment may apply.

Contact: Please apply with a resume to Dr. Kachhap (kachhsu@jhmi.edu)

Sincerely,
Sushant Kachhap

The Department of Pediatrics at the Johns Hopkins University School of Medicine is seeking a highly motivated postdoctoral research fellow to join our NIH-funded research group directed by Dr. Ling He. The research projects of Dr. He’s lab focus on the study of the development of fatty liver in obese model, mitochondrial dysfunction and the changes of intestinal microbiota in affecting liver metabolism. We are a growing research team and have started a new study of nonalcoholic fatty liver disease, a critical area of obesity research. The candidate will be expected to help other fellows and research staff who are working on the roles of AMPK in regulating liver glucose production, and work in a cooperative manner with other employees in our division. The nature of this position requires that you take a high degree of personal responsibility for the smooth operation of the lab. This job requires quality work and high productivity to ensure continued success of our group. The candidate will also participate in teaching of undergraduates, graduate students, medical residents, and fellows in laboratory-based research.

Candidates should have a PhD and/or MD or equivalent degree, with a strong background in Virology, Immunology, especially Innate immunity and is eligible to work in the United States. The candidate must be enthusiastic toward research projects, have excellent critical thinking skills, a track-record of productivity as demonstrated by first-author peer-reviewed publications, an ability to work well both independently and as part of a team, and proficiency in written and oral English communication.

A successful candidate will have the opportunity to lead independent and cutting-edge research projects with a world-class research facility. We will also provide a customizable curriculum, individual career development/support, and Interdisciplinary and collaborative research community.

This position is available immediately. Salary will commensurate with research experience.

To apply, please send 1) a cover letter with a brief statement of research experience and future proposed interests, 2) contact information of at least 3 references (at least one from former direct mentor) , and 3) a detailed curriculum vitae to: Dr. Ling He (heling@jhmi.edu ) and Debbi Stroback (debbi@jhu.edu). 

A post-doctoral fellowship is available immediately in the Brain Cancer Biology and Research Laboratory in the Department of Neurosurgery in the Johns Hopkins University School of Medicine. Support for this brain cancer research is provided by NIH grants with additional support from a variety of competitive peer reviewed grants and endowed funding. The laboratory P.I. is Professor Gregory J. Riggins, MD, PhD the Irving J. Sherman Research Professor of Neurosurgery and Oncology. Interested candidates are encouraged to view online our recent publicly accessible publications.

The primary focus of research for this position is the NCI R01 grant, “Optimizing demethylating therapy for IDH1 Mutant Malignant Gliomas” (grantome.com/grant/NIH/R01-CA190223-02). This work is now in its seventh year of NIH funding. It aims to understand how inducing epigenetic changes and combination therapy in these brain cancers of young adults can be exploited to slow or stop tumor growth.

The mission for this laboratory is to develop improved therapies for nervous system tumors and metastatic cancers to the brain, and to understand the molecular and immunological mechanisms of promising new therapies.

The qualified candidate will have a Ph.D. or MD/PhD in a cancer research or molecular biology related discipline. Current molecular biology skills are essential, and those with cancer and mouse models research, including brain cancer research experience, are preferred.

Support for this translational cancer research is provided by the National Institutes of Health, the Neurofibromatosis CDMRP, endowments and generous private donations.

Interested candidates who want to apply should please send a cover letter and a current CV to griggin1@jhmi.edu. 

Highly motivated postdoctoral scientists are invited to lead several new projects to address fundamental questions on protein homeostasis (Lu et al., PLoS Biology 2021; Lu et al. Nature Neuroscience 2019), DNA/RNA and their binding proteins (Haeusler et al. Nature 2014; Liu et al. Neuron 2023), and metabolism (Wang et al., Cell Metabolism 2021) related to neurodegenerative diseases in the laboratory of Jiou Wang. The position is open to candidates with a wide range of backgrounds including biochemistry, molecular biology, cell biology, and structural biology on all topics of biology. Those with experience in molecular and cell biology, nucleic acid biology, protein biochemistry, and bioinformatics are particularly encouraged to apply.

The Johns Hopkins Medical Institutions provide a stimulating and collaborative environment for biomedical research. Our lab is affiliated with the Department of Biochemistry and Molecular Biology at the Bloomberg School of Public Health and the Department of Neuroscience at the School of Medicine. The Baltimore/Washington D.C. area also offers rich professional and living opportunities.

Candidates should have a doctoral degree and strong research background. Please send a statement of research experience and career goals, a copy of Curriculum Vitae, and contact information of at least one reference to Dr. Jiou Wang at jiouw@jhmi.edu.

A complete listing of PubMed-accessible publications can be accessed at the following URL: http://www.ncbi.nlm.nih.gov/pubmed/?term=Jiou+Wang.

More information available at: http://www.jhu-bmb-phd.org/faculty/jiou-wang. The Johns Hopkins University is an Equal Opportunity Employer.

We are seeking a highly motivated postdoctoral researcher to join our multidisciplinary team of scientists and physicians on a portfolio of projects focused on leveraging network science, phylodynamics, and deep learning to develop targeted HIV and hepatitis C virus (HCV) interventions for people who inject drugs (PWID).

Minimum Qualifications:

• Have a Ph.D. in a subject area related to bioinformatics, machine learning, network science, computational epidemiology, or infectious disease modeling (e.g., Computer Science, Applied Mathematics, Statistics, Engineering, Infectious Disease Epidemiology, Genetic Epidemiology, etc.) and have significant experience with deep learning or phylogenetics, as demonstrated in recent publications.
• Experience analyzing large datasets and developing statistical models.

• Strong programming skills in Python and R.
• Experience with network analysis, machine learning, and/or viral phylogenetics.
• Excellent communication and collaboration skills.

Duties & Responsibilities:

• Analyze and interpret longitudinal social and spatial network data, individual-level data, and HIV/HCV next-generation sequencing data.
• Conduct biostatistical analyses using a range of standard analytical techniques, including regression, nonparametric methods, and machine learning approaches.
• Conduct bioinformatic analyses in a command line environment on high-performance computing clusters (e.g., MARCC), including the ability to perform batched sample analysis, QC, adapter trimming, alignment of next-generation sequencing data, and subsequent additional analysis.
• Create and maintain systems for archiving analytic results and other research information.
• Explore the use of deep learning methods, such as graph neural networks (GNNs), for imputing network data.
• Develop and validate network models that simulate the effect of various network-based intervention strategies on disease incidence.
• Communicate research findings to scientific and lay audiences through publications, presentations, and other dissemination strategies.

• Write statistical analysis sections for funding applications, research protocols, and manuscripts.

Desired Knowledge, Skills, and Abilities:

• Applied knowledge of advanced biostatistical and bioinformatic methods with proficiency in multiple software packages and tools (e.g., BEAST, Jupyter, GitHub, NetworkX, PyTorch).
• Excellent data management skills with proficiency in REDCap.
• Strong familiarity with epidemiologic principles.
• Prior experience with phylogenetics with skills in network and cluster analyses.
• Strong data visualization skills. Experience generating figures for network and omics analyses preferred.
• Ability to act proactively and independently, exercising good judgment, and thinking creatively to overcome data management and statistical analysis challenges.

To apply, please submit a CV, a cover letter describing your research interests and experience, and contact information for three references to Dr. Steven Clipman (sclipman@jhmi.edu). Applications will be reviewed on a rolling basis until the position is filled.

The Karantanos lab in the Division of Hematologic Malignancies, Department of Medical Oncology at the Johns Hopkins University School of Medicine is seeking candidates for a post-doctoral research position.

We are a molecular biology lab focusing on myeloid malignancies. The goals of our lab are 1) to understand the implication of inflammatory signaling and particularly CCRL2/STAT1 pathway in the progression of myelodysplastic syndrome (MDS), myeloproliferative neoplasms (MPN) and acute myeloid leukemia (AML) and 2) to develop therapeutic strategies target MDS/AML cells with upregulated inflammatory pathways. To do this, we utilize gene editing using CRISPR-Cas9 technology, proteomics studies, drug screens, analysis of primary patient tumor cells, AML and MDS xenograft models in immunodeficient mice and correlative primary clinical data. Our emphasis is on myeloid malignancies, but our studies have significant implications to other cancer types including glioblastoma and investigate basic mechanisms of signal transduction and concepts of synthetic lethality. Current projects include 1) dissecting the impact of CCRL2/STAT1 signaling on the progression of MDS/AML; 2) investigating mechanisms of resistance to JAK1/2 inhibitors in myeloid neoplasms; 3) discovering agents with selective efficacy against CCRL2-expressing MDS/AML cells; 4) developing a high-risk MDS/MPN xenograft model using primary cells from patients.

You can find more information about the lab here: https://www.hopkinsmedicine.org/profiles/details/theodoros-karantanos

You can visit Dr. Karantanos’ bibliography here: https://scholar.google.com/citations?user=boJ6-cwAAAAJ

Candidates must be recent M.D. or Ph.D. graduates. The ideal candidate should have some exposure to standard molecular and cell biology techniques. The additional skill including flow cytometry, western blotting, and molecular cloning would be highly desired.

Interested applicants should send the following materials, by email to Dr. Theodoros Karantanos (tkarant1@jhmi.edu):

1. Cover letter indicating current and future research interests, as well as a brief summary of previous research experiences
2. Expected starting date
3. Curriculum vitae
4. Names and contact information for 3 references

The fellowship provides an annual salary commiserate with NIH guidelines for PGY level with full healthcare benefits. Postdoctoral scientists will be employees of Johns Hopkins University, an Equal Opportunity/Affirmative Action Employer. Applicants are not required to be United States citizens.